MHC Typing

Bio-tag offers high standard secure and confidential storage of DNA to institutions, corporate customers and businesses for identity testing purposes.

MHC genotyping of dogs and cats.
MHC genes and the immune response

Genes within the major histocompatibility complex (MHC) are largely responsible for the regulation and genetic control of immune responses. These genes, present in Man and all higher animals exhibit extreme polymorphism (i.e. they are found within a single species in many different variant forms).

Variation within the MHC genes may explain why some individuals make strong or alternatively weak responses to vaccination. It also largely determines why some individuals are highly susceptible to particular infections, cancers or autoimmune diseases whilst others are resistant. Differences in MHC gene types between donors and recipients are often responsible when transplanted tissue, such as a kidney is rejected by the immune system.

Scientists within bio-tag are at the forefront of characterising MHC gene variation in dogs and cats. They have also determined MHC types in different dog breeds and diseases.

MHC Services
Bio-tag offers DNA based dog and cat MHL genotyping for academic and industrial veterinary research groups investigating underlying causes of disease susceptibility and variation in the immune response in dogs and cats.

Bio-tag currently offers genotyping for the following MHC genes
DLA-DRB1, DLA-DQB1, DLA-DQA1, DLA-TNFalpha, FLA-DRB1.

For further details and prices of MHC genotyping services please contact us at enquiries@bio-tag.com